Forskolin is a weight loss and bodybuilding supplement, which has gained attention in the market. This is also marketed as Colforsin and Coleonol as well. This is an organic compound derived from the root roots of Indian Coleus plants. Seems to have gained some visibility after being shown by Dr. Oz on one of his shows.
Indian Coleus plants have been used for medicinal purposes for centuries. As part of the Ayurvedic medicine tradition (Ancient Indian medicine) it is used to treat various heart conditions including high blood pressure, chest pain (angina), painful urination, convulsions and respiratory disorders such as asthma.
Unfortunately very little science has gone behind the modern claims about the benefits of this herb medicine. It seems that opportunistic marketers today don't care about thorough research but begin to turn on their campaigns in the slightest hint of what might be far effective.
To return to the subject matter, there is only one peer-reviewed scientific study conducted on Forskolin published in scientific journals. This study shows a significant effect in men who are overweight and obese. This reduces body fat percentage and body fat mass. It also increases lean bone mass and serum testosterone levels in overweight and obese men. One must pay attention that research is done only on men! Only one clear scientific study is not enough to build the credibility of supplement products.
Forskolin activates the enzyme adenylyl cyclase. This enzyme is involved in sending chemical signals from outside the cell, through the cell membrane to the inside of the cell. The next effect is an increase in the level of chemical couriers called cyclic AMP (Adenosine monophosphate) or in short. cAMP is an important messenger in many biological processes. This is responsible for transferring the effects of hormones such as adrenaline, which cannot pass through the cell membrane, to the inside of the cell. Furthermore, it plays a role in the regulation of glycogen, sugar and lipid metabolism. It is believed, because of this activation mechanism, it might play a role in reducing body fat and increasing lean bone mass.
Although fat reduction and the effect of increasing bone mass have not been widely studied, one of the effects of Forskolin observed is vasodilators and bronchodilators. It has been consistently observed to reduce blood pressure. It has been observed to effectively reduce asthma attacks. Given this, one must be careful, when using it as a weight-loss supplement, because you take blood pressure-lowering drugs such as calcium channel blockers or beta blockers, Forskolin will work together with these drugs and there will be an additional effect of pressure drop blood and it can turn out to be a serious problem. Just as high blood pressure is not good, low blood pressure is also significantly not good.
In laboratory studies in test tubes and in animals, it has been observed that Forskolin interacts with melanin under the skin and the effect it produces is tanning! Don't be surprised if it is claimed that the same miracle drug will lose weight, help build the body and will do tanning at the same time without going to the sun !!